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Showing 1 to 12 of 1323 entries
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Guarana (.

Toxicology research

Arantes LP, Peres TV, Chen P, Caito S, Aschner M, Soares FA.
PMID: 28316775
Toxicol Res (Camb). 2016 Nov 01;5(6):1629-1638. doi: 10.1039/C6TX00161K. Epub 2016 Aug 24.

The influence of routine guarana (

Inhibition of Carcinogen-Activating Cytochrome P450 Enzymes by Xenobiotic Chemicals in Relation to Antimutagenicity and Anticarcinogenicity.

Toxicological research

Shimada T.
PMID: 28443179
Toxicol Res. 2017 Apr;33(2):79-96. doi: 10.5487/TR.2017.33.2.079. Epub 2017 Apr 15.

A variety of xenobiotic chemicals, such as polycyclic aromatic hydrocarbons (PAHs), aryl- and heterocyclic amines and tobacco related nitrosamines, are ubiquitous environmental carcinogens and are required to be activated to chemically reactive metabolites by xenobiotic-metabolizing enzymes, including cytochrome P450...

Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction.

Toxicological research

Chun SK, Go K, Yang MJ, Zendejas I, Behrns KE, Kim JS.
PMID: 26977257
Toxicol Res. 2016 Jan;32(1):35-46. doi: 10.5487/TR.2016.32.1.035. Epub 2016 Jan 31.

No-flow ischemia occurs during cardiac arrest, hemorrhagic shock, liver resection and transplantation. Recovery of blood flow and normal physiological pH, however, irreversibly injures the liver and other tissues. Although the liver has the powerful machinery for mitochondrial quality control,...

Different Regulation of p53 Expression by Cadmium Exposure in Kidney, Liver, Intestine, Vasculature, and Brain Astrocytes.

Toxicological research

Lee JY, Tokumoto M, Hattori Y, Fujiwara Y, Shimada A, Satoh M.
PMID: 26977261
Toxicol Res. 2016 Jan;32(1):73-80. doi: 10.5487/TR.2016.32.1.073. Epub 2016 Jan 31.

Chronic exposure to cadmium (Cd) is known to adversely affect renal function. Our previous studies indicated that Cd induces p53-dependent apoptosis by inhibiting gene expression of the ubiquitin-conjugating enzyme (Ube) 2d family in both human and rat proximal tubular...

Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury.

Toxicological research

Cheon JH, Kim SY, Son JY, Kang YR, An JH, Kwon JH, Song HS, Moon A, Lee BM, Kim HS.
PMID: 26977258
Toxicol Res. 2016 Jan;32(1):47-56. doi: 10.5487/TR.2016.32.1.047. Epub 2016 Jan 31.

The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr)...

Inhibition of Cytochrome P450 by Propolis in Human Liver Microsomes.

Toxicological research

Ryu CS, Oh SJ, Oh JM, Lee JY, Lee SY, Chae JW, Kwon KI, Kim SK.
PMID: 27437087
Toxicol Res. 2016 Jul;32(3):207-13. doi: 10.5487/TR.2016.32.3.207. Epub 2016 Jul 30.

Although propolis is one of the most popular functional foods for human health, there have been no comprehensive studies of herb-drug interactions through cytochrome P450 (CYP) inhibition. The purpose of this study was to determine the inhibitory effects of...

Propolis Inhibits Neurite Outgrowth in Differentiating SH-SY5Y Human Neuroblastoma Cells.

Toxicological research

Kim HB, Yoo BS.
PMID: 27437091
Toxicol Res. 2016 Jul;32(3):239-43. doi: 10.5487/TR.2016.32.3.239. Epub 2016 Jul 30.

Propolis is a multicomponent, active, complex resinous substance collected by honeybees from a variety of plant sources. We have studied the effect of propolis on neurite outgrowth of SH-SY5Y human neuroblastoma cells induced to differentiate by all-trans-retinoic acid (RA)....

Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice.

Toxicological research

Lee BH, Lee JS, Kim YC.
PMID: 27123160
Toxicol Res. 2016 Apr;32(2):103-8. doi: 10.5487/TR.2016.32.2.103. Epub 2016 Apr 30.

The purpose of this study was to determine the hair growth effects of lavender oil (LO) in female C57BL/6 mice. The experimental animals were divided into a normal group (N: saline), a vehicle control group (VC: jojoba oil), a...

Effect of Thiol-reducing Agents and Antioxidants on Sulfasalazine-induced Hepatic Injury in Normotermic Recirculating Isolated Perfused Rat Liver.

Toxicological research

Heidari R, Esmailie N, Azarpira N, Najibi A, Niknahad H.
PMID: 27123164
Toxicol Res. 2016 Apr;32(2):133-40. doi: 10.5487/TR.2016.32.2.133. Epub 2016 Apr 30.

Sulfasalzine is a widely administered drug against inflammatory-based disorders in human. However several cases of liver injury are associated with its administration. There is no stabilized safe protective agent against sulfasalazine-induced liver injury. Current investigation was designed to evaluate...

Analysis of 3-MCPD and 1,3-DCP in Various Foodstuffs Using GC-MS.

Toxicological research

Kim W, Jeong YA, On J, Choi A, Lee JY, Lee JG, Lee KG, Pyo H.
PMID: 26483891
Toxicol Res. 2015 Sep;31(3):313-9. doi: 10.5487/TR.2015.31.3.313.

3-Monochloro-1,2-propanediol (3-MCPD) and 1,3-dichloro-2-propanol (1,3-DCP) are not only produced in the manufacturing process of foodstuffs such as hydrolyzed vegetable proteins and soy sauce but are also formed by heat processing in the presence of fat and low water activity....

Modulation of Apoptosis and Differentiation by the Treatment of Sulfasalazine in Rabbit Articular Chondrocytes.

Toxicological research

Lee WK, Kang JS.
PMID: 27123162
Toxicol Res. 2016 Apr;32(2):115-21. doi: 10.5487/TR.2016.32.2.115. Epub 2016 Apr 30.

This study was conducted to examine the cellular regulatory mechanisms of sulfasalazine (SSZ) in rabbit articular chondrocytes treated with sodium nitroprusside (SNP). Cell phenotype was determined, and the MTT assay, Western blot analysis and immunofluorescence staining of type II...

Distribution of Seven N-Nitrosamines in Food.

Toxicological research

Park JE, Seo JE, Lee JY, Kwon H.
PMID: 26483887
Toxicol Res. 2015 Sep;31(3):279-88. doi: 10.5487/TR.2015.31.3.279.

N-nitrosamines, which are classified as carcinogens by IARC and US EPA, can be easily found in various foods. They are reaction products between nitrogen oxide and secondary amines, but can also be generated during fermentation. Ever since the 1960s,...

Showing 1 to 12 of 1323 entries